Photo credit: Cannabis Culture

Not many people are given good instructions on how to get to sleep. Up until recently, it’s been posed as a binary, and indeed, the more stress you put on oneself, the less likely you’re going to get the sleep one needs. The moment to start preparing begins, interestingly enough, when you first wake up. According to sleep scientist Matthew Walker, both your circadian rhythms and the sleep pressure built up by the steady increase of adenosine throughout the day will eventually intersect to bring your waking life to a halt. But over time, for various reasons, this mechanism may only work so well for some people, and will therefore need some assistance with the proper lifestyle and dietary choices. Herbs such as valerian, lemon balm and skullcap may help with that.

Medicine Box has worked with these and a few other herbs for many years to create our prize-winning Equanimity sleep tincture — or formulation, as we prefer to call it around here, and we’ve learned quite a bit about them. So we’re going to drill down into both the ancient wisdom and the modern science that surrounds some of our formulary choices.


Five awesome potentials for CBG (Cannabigerol)

Gut health

As we spoke to last week, the endocannabinoid system is heavily represented in our gut, particularly in epithelial tissue, and while we’re still determining how CBG interacts with the ECS overall, one study with mice has shown CBG to reduce oxidative stress and inflammation in a chemically-induced case of Inflammatory bowel disease. Even more dramatically, a study in Israel showed both CBG and cannibichromine, for which the acidic version of CBG serves as a precursor, was shown to kill gastrointestinal cancer cells in tissue culture. Could this work in the GI tract? That remains to be seen.


CBG also engages the serotonin receptor 5-HT1A as an antagonist, and it also does the same with the TRPV family of receptors. CBD, interestingly enough, also interacts with some these receptors as well. What this means is that CBG may work against the stress and anxiety that can lead to depression, and even impact on pain as well. Some users have already begun to explore it for themselves.



CBG also holds out hope as an antibacterial agent, particularly against the staph infection MRSA. A recent Canadian study found that CBG killed MRSA in a rat model, which bodes well for potential tests in humans. 


+ Ease

Tied into CBG’s soothing effects are CBG’s preliminary characteristics as a muscle relaxant. This can help with those looking to recuperate from exercise, or just life itself. 



One apparent side effect is that it can act as an appetite stimulant – perhaps not the greatest thing in the world if you’re trying to go on a diet, but great if you’re just beginning a full meal you wish to savor.

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The beginnings of usage


It’s still early days for CBG, which means people are determining dosages for themselves. This is why we invite people to join us on our social media channels, where we and the Medicine Box community discuss our products and how to use them frequently. Ultimately, no one molecule or compound is the answer. Any product’s effects are inseparable from the larger environment  and however much of the Seven Pillars – food, music, mindfulness, nature, collaboration, community and recovery – that you have in your life.

One thing we will say in closing: the further away you get from nature , the further away you get from real healing. We’ve been hearing a lot about the rise of synthetic CBG, which is a direction we at Medicine Box Wellness will never take. It may cost a little more, but it’s worth it to bestow authentic healing for those in need